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To validate this effect in mice, we performed hyperinsulinemic-euglycemic clamps in Dpp4 +/+ (wild-type, WT) and Dpp4 / (global Dpp4 deletion) mice fed a high-fat, high-cholesterol (HFHC) diet for 12 weeks

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When Selinexor combined with high-dose anti-PD-L1 antibodies, the tumors in mice completely subsided and produced lasting immune control, which is expected to become a key force in the treatment of osteosarcoma